Research Interests
Prof. Xiaojun Chen is with Institute of Biomedical Manufacturing, School of Mechanical Engineering, Shanghai Jiao Tong University (SJTU), China. He received his Ph.D from SJTU in 2006, and then furthered his research as a postdoctoral fellow at the same institution until 2008. After that, he has been working at SJTU as assistant professor (2008-2010), associate professor (2010-2018), professor(2018-now), and tenured professor(2025-now). His research focuses on biomedical image analysis, image-guided interventions, artificial intelligence in biomedical physics and analysis, VR/AR/MR technology in medicine, medical robotics, biomedical manufacturing, etc. As a visiting professor, he had worked at the Surgical Planning Laboratory, Harvard Medical School during Oct 2011~ Oct 2012; the TIMC-IMAG lab, CNRS, France during Sep~Dec 2013; the OMFS-IMPATH lab, KU Leuven, Belgium during Jun~Aug 2015, and the CISTIB lab, the University of Sheffield, UK during Jun~ Aug 2016.
He is the author and co-author of more than 200 peer-reviewed journal/conference articles in MedIA, IEEE-TMI, IEEE-TBME, IEEE-TVCG, CMIG, CMPB, IJCARS, etc., the owner of more than 30 patents, and have delivered more than 50 lectures in the prestigious international conferences including IEEE-EMBC, IEEE-ITAB, MICCAI, CARS, iSMIT, CAI, etc. He was granted Second Prize of National Science & Technology Progress Award of China (2019), Chinese Society of Stomatology Science and Technology Award (2018), Jiangsu Province Science & Technology Award (2017,2025), China Medical Science and Technology Award (2016), Shanghai Science & Technology Award (2010), Shanghai Medical Science & Technology Award (2008).
Selected Publications
He is the author and co-author of more than 200 peer-reviewed journal/conference articles in Medical Image Analysis, IEEE-TMI, etc. The recent representative journal papers published as last corresponding author are listed as follows:
(1) Puxun Tu, Hongfei Ye, Haochen Shi, Jeff Young, Meng Xie, Peiquan Zhao, Ce Zheng, Xiaoyi Jiang, Xiaojun Chen.Phase-specific augmented reality guidance for microscopic cataract surgery using spatiotemporal fusion network. Information Fusion. 2025; 113:102604.
(2) Jiangchang Xu, Yining Wei, Shuanglin Jiang, Huifang Zhou, Yinwei Li, Xiaojun Chen. Intelligent surgical planning for automatic reconstruction of orbital blowout fracture using a prior adversarial generative network. Medical Image Analysis. 2025; 99:103332.
(3) Haitao Li, Xingqi Fan, Baoxin Tao, Wenying Wang, Yiqun Wu, Xiaojun Chen. ZygoPlanner: A three-stage graphics-based framework for optimal preoperative planning of zygomatic implant placement. Medical Image Analysis. 2025; 101: 103401.
(4) Dongyuan Li, Yixin Shan, Haochen Shi, Puxun Tu, Shenghao Huang, Weiyan Sun, Deping Zhao, Chang Chen, Xiaojun Chen. A novel image-guided robotic system with motion compensation for intraoperative radiation-free localization of pulmonary nodules. Medical Image Analysis. 2025; 105: 103691.
(5) Yan Guo, Chenyao Li, Rong Yang, Puxun Tu, Bolun Zeng, Jiannan Liu, Tong Ji, Chenping Zhang, Xiaojun Chen. Automated planning of mandible reconstruction with fibula free flap based on shape completion and morphometric descriptors. Medical Image Analysis. 2025; 102: 103544
(6) Haochen Shi, Jiangchang Xu, Haitao Li, Shuanglin Jiang, Chaoyu Lei, Huifang Zhou, Yinwei Li, Xiaojun Chen. A novel spatial-temporal image fusion method for augmented reality-based endoscopic surgery. Medical Image Analysis. 2025; 103: 103609
(7) Qianwen Ji, Yizhou Chen, Xiaojun Chen. Template-based Semantic-Guided Orthodontic Teeth Alignment Previewer. Medical Image Analysis. 2026;107:103802
(8) Dongyuan Li, Yixin Shan, Yuxuan Mao, Puxun Tu, Haochen Shi, Shenghao Huang, Weiyan Sun, Chang Chen, Xiaojun Chen. Robust non-rigid image-to-patient registration for contactless dynamic thoracic tumor localization using recursive deformable diffusion models. Medical Image Analysis. 2026;110:103948
(9) Yi Zhang, Yulin Yan, Kun Wang, Muyu Cai, Yifei Xiang, Yan Guo, Puxun Tu, Tao Ying, Xiaojun Chen. A navigation-guided 3D breast ultrasound scanning and reconstruction system for automated multi-lesion spatial localization and diagnosis. Medical Image Analysis. 2026;110:103965
(10) Bolun Zeng, Yaolin Xu, Peng Wang, Tianyu Lu, Zongyu Xie, Mengsu Zeng, Jianjun Zhou, Liang Liu, Haitao Sun, Xiaojun Chen. C2HFusion: Clinical context-driven hierarchical fusion of multimodal data for personalized and quantitative prognostic assessment in pancreatic cancer. Medical Image Analysis. 2026;109: 103937
(11) Jiangchang Xu, Weiqing Tang, Pheng-Ann Heng, Xiaojun Chen. Automatic prediction of depth of invasion in oral tongue squamous cell carcinoma using a multimodal regression network fusing prior text and anatomical knowledge. Medical Image Analysis. 2026;107:103824
(12) Jiaxuan Liu, Haitao Li, Haochen Shi,Wei Huang, Zhongmin Wang, Valentina D A Corino, Xiaojun Chen. BrachyPlan: A Fine-grained Efficient Dose-guided Inverse Planning Strategy for Low-dose-rate Brachytherapy. Medical Image Analysis. 2026;107:103852
(13) Bolun Zeng, Huixiang Wang, Xingguang Tao, Haochen Shi, Leo Joskowicz, Xiaojun Chen. A bidirectional framework for fracture simulation and deformation-based restoration prediction in pelvic fracture surgical planning. Medical Image Analysis. 2024; 97:103267.
(14) Yan Guo, Chenyao Li, Haitao Li, Weiwen Ge, Bolun Zeng, Jiaxuan Liu, Tianhao Wan, Shanyong Zhang, Xiaojun Chen. Automated Orthognathic Surgery Planning based on Shape-Aware Morphology Prediction and Anatomy-Constrained Registration. IEEE Transactions on Image Processing. 2026; doi: 10.1109/TIP.2026.3651981
(15) Enpeng Wang, Jiangchang Xu, Yueang Liu, Puxun Tu, Junfeng Wang, Xiaoyi Jiang, Xiaojun Chen. Robust Self-Supervised Monocular Depth Estimation for Endoscopic Soft Tissue Deformation Scenes with Biomechanical Constraints. IEEE Transactions on Image Processing. 2026; doi: 10.1109/TIP.2025.3650051
(16) Jiaxuan Liu, Haitao Li, Bolun Zeng, Huixiang Wang, Ron Kikinis, Leo Joskowicz, Xiaojun Chen. An End-to-End Geometry-Based Pipeline for Automatic Preoperative Surgical Planning of Pelvic Fracture Reduction and Fixation. IEEE Transactions on Medical Imaging.2025; 44(1):79-91
(17) Enpeng Wang, Yueang Liu, Puxun Tu, Zeike A. Taylor, Xiaojun Chen. Video-based Soft Tissue Deformation Tracking for Laparoscopic Augmented Reality-based Navigation in Kidney Surgery. IEEE Transactions on Medical Imaging.2024; 43(12):4161-4173
(18) Bolun Zeng, Huixiang Wang, Jiangchang Xu, Puxun Tu, Leo Joskowicz, Xiaojun Chen. Two-Stage Structure-focused Contrastive Learning for Automatic Identification and Localization of Complex Pelvic Fractures. IEEE Transactions on Medical Imaging. 2023. 42(9): 2751-2762
(19) Bolun Zeng, Li Chen, Yuanyi Zheng, Xiaojun Chen. Adaptive Multi-dimensional Weighted Network with Category-aware Contrastive Learning for Fine-grained Hand Bone Segmentation. IEEE Journal of Biomedical and Health Informatics.2024;28(7):3985-3996. (Cover and featured paper)
(20) Yi Zhang, Bolun Zeng, Jia Li, Yuanyi Zheng, Xiaojun Chen. A Multi-Task Transformer with Local-Global Feature Interaction and Multiple Tumoral Region Guidance for Breast Cancer Diagnosis. IEEE Journal of Biomedical and Health Informatics. 2024;28(11): 6840-6853.
(21) Jiangchang Xu, Jie Gao, Shuanglin Jiang, Chunliang Wang, ?rjan Smedby, Yiqun Wu, Xiaoyi Jiang, Xiaojun Chen. Automatic Segmentation of Bone Graft in Maxillary Sinus Via Distance Constrained Network Guided by Prior Anatomical Knowledge. IEEE Journal of Biomedical and Health Informatics. 2025; 29(3):1995-2005. (Featured paper)
(22) Mingjun Gong, Xiaojun Chen. 3D Surface-Closed Mesh Clipping Based on Polygonal Partitioning for Surgical Planning. IEEE Transactions on Visualization and Computer Graphics. 2024; 30 (7): 3374-3385.
(23) Yizhou Chen, Shuojie Gao, Puxun Tu, Xiaojun Chen. Automatic 3D Teeth Reconstruction from Five Intra-oral Photos Using Parametric Teeth Model.IEEE Transactions on Visualization and Computer Graphics. 2024;30(8): 4780-4791.
(24) Puxun Tu, Pingping Hu, Junfeng Wang, Xiaojun Chen. From Coarse to Fine: Non-Rigid Sparse-Dense Registration for Deformation-Aware Liver Surgical Navigation. IEEE Transactions on Biomedical Engineering. 2024; 71(9): 2663-2677.
(25) Puxun Tu, Chunxia Qin, Yan Guo, Dongyuan Li, Abel J Lungu, Huixiang Wang, Xiaojun Chen. Ultrasound image guided and mixed reality-based surgical system with real-time soft tissue deformation computing for robotic cervical pedicle screw placement. IEEE Transactions on Biomedical Engineering. 2022; 69 (8): 2593 2603.
(26) Yueang Liu, Enpeng Wang, Mingjun Gong, Baoxin Tao, Yiqun Wu, Xiangdong Qi, Xiaojun Chen. Geometric-Driven Cross-Modal Registration Framework for Optical Scanning and CBCT Models in AR-Based Maxillofacial Surgical Navigation. IEEE Transactions on Biomedical Engineering. 2025; DOI: 10.1109/TBME.2025.3606469.
(27) Afaque Rafique Memon, Haochen Shi, Tarique Rafique Memon, Jan Egger, Xiaojun Chen. Deep learning-based automatic cranial implant design through direct defect shape prediction and its comparison study. Medical & Biological Engineering & Computing.2025;63: 2815-2826. (Cover paper)
Other Professional Activities
He is the Co-Program Chair of the 30th MICCAI(2027), Deputy Editor of International Journal of Computer Assisted Radiology and Surgery(Deputy Editor: 2026-now, Editorial Board member: 2015-2025), Medical Engineering & Physics(Deputy Editor: 2020-2025, Executive Editorial Board member: 2025-now), Executive Editorial Board Member of Physics in Medicine & Biology (IOP), Associate Editor of Computerized Medical Imaging and Graphics(Elsevier), Physical and Engineering Sciences in Medicine (Springer), Computer Assisted Surgery(Taylor & Francis), IEEE Transactions on Medical Robotics and Bionics, and Editorial Board Member of International Journal of Medical Robotics and Computer Assisted Surgery (Wiley),etc., Editorial Advisory Board member of Journal of Mechanics in Medicine and Biology etc., a guest editor of Frontiers Robotics and AI and a scientific board member of the CAI (the International Academy of Computer Aided Implantology) academy, the DDS (the International Digital Dentistry Society), Chinese Digital Orthopedics Society of SICOT (the Société Internationale de Chirurgie Orthopédique et de Traumatologie), Medical Imaging Committee of the Chinese Society of Image and Graphics (CSIG), Expert Committee of the Chinese Medical Robot Standardization, IEEE member, etc. Since 2008, he has been a regular reviewer of Nature Communications, MedIA, IEEE-TMI, IEEE-TIP, IEEE-TBME, IEEE-JBHI, IEEE-TMECH, IJCARS, IJMRCAS, CMIG, CMPB, CIBM, CMBBE, ERMD, PMB, MEP, CAS, etc. and edited 5 special issues for Frontiers Robotics and AI, Electronics (Bioelectronics Section) and Computer Assisted Surgery. Especially, he was awarded IEEE Transactions on Medical Imaging Distinguished Reviewer twice(2023-2024, 2020-2022) and Computerized Medical Imaging and Graphics Outstanding Reviewer in 2022.
